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李春權

v  1979年9月出生,哈爾濱醫科大學,大慶校區醫學信息學系,系副主任(正科級)、博士,副教授,碩士研究生導師。大慶市勞動模范獲得者,哈爾濱醫科大學青年五四獎章獲得者,于維漢院士杰出青年培養基金獲得者,哈爾濱醫科大學十大青年科技人才獎獲得者,黑龍江省優秀博士論文獲得者,人民衛生出版社出版《生物信息學理論與醫學實踐》一書擔任編委,全國性生物信息學培訓班教師(共三期),全國生物信息暑期學校培訓教師,全國生物信息骨干教師培訓班講座教師。研究方向是“復雜疾病相關的代謝通路重構、分析和識別”。

v  迄今已累計發表SCI研究論文43篇。第1作者、并列第1作者論文或通訊作者論文30篇,其中SCI影響因子>5的論文13篇。分別發表在英國牛津出版集團出版的《Nucleic Acids Research》(三篇)、《Bioinformatics》、英國自然出版集團出版的自然系列子刊《SCIENTIFIC REPORTS》、《Human Mutation》、《BMC bioinformatics》、《BioMed Research International》、《Gene》、《Journal of Biomedical Informatics》、《 PLoS ONE》、《Asian Pacific Journal of Cancer Prevention: APJCP》等雜志上。作為項目負責人,承擔國家自然科學基金青年面上項目、國家自然科學基金青年基金項目、國家教育部高等學校博士點學科專項科研基金項目、于維漢院士杰出青年培養基金、黑龍江省自然科學基金面上項目、黑龍江省教育廳科學技術研究項目等課題。研究成果分別獲得黑龍江省自然科學技術學術成果獎一等獎(排名第1)和中華醫學科技獎三等獎(排名第5)。開發的SubpathwayMiner等子通路識別相關軟件平臺被高影響力的頂級綜述雜志《Nature reviews cancer》(SCI影響因子=37.9)所引用,并且被列入雜志論文的通路識別軟件列表,推薦給各國的癌癥研究人員使用該系統。同時被列入的通路識別軟件GSEA、SPIA等均為國際最著名的通路識別軟件之一,表明SubpathwayMiner軟件平臺已進入國際主流通路識別軟件行列。SubpathwayMiner等相關軟件平臺2011年也被美國化學綜述雜志《CHEMICAL REVIEWS》(SCI影響因子=40.2)、美國年度綜述雜志《ANNUAL REVIEWS》(SCI影響因子=21.6)兩大國際頂級雜志所引用和推薦研究人員使用。另外,該平臺也多次被國際專業領域高影響力的雜志,例如生物信息學領域頂級綜述雜志《Briefings in Bioinformatics》、藥物領域高影響力??禗RUG DISCOVERY TODAY》、《Clinical Pharmacoligy&Therapeutics》等引用或報道。目前SubpathwayMiner相關分析平臺已被美國、英國、德國、日本、加拿大、韓國等幾十個國家的研究機構使用。

教育經歷(按時間倒排序):

v  2009/09-2012/07,哈爾濱醫科大學,生物物理學專業(生物信息學方向),博士。

v  2003/09-2005/07,哈爾濱工業大學,計算機科學與技術專業,碩士。

v  1998/09-2002/07,大連海事大學,輪機工程專業,學士。

研究工作經歷(科研與學術工作經歷,按時間倒序排序):

v  2012/10 - 至今,哈爾濱醫科大學,生物信息科學與技術學院/大慶校區醫學信息學院,副教授。

v  2009/10-2012/09,哈爾濱醫科大學,生物信息科學與技術學院,講師。

v  2005/08-2009/09,哈爾濱醫科大學,生物信息科學與技術學院,助教。

主持或參加科研項目及人才計劃項目情況(按時間倒序排序):

v  國家自然科學基金面上項目,81572341、食管癌中非編碼RNA調控的代謝通路高異常區域識別及其分子互作機制、2016/1-2019/12、67.8萬元、在研、主持。

v  黑龍江省自然科學基金面上項目,F2016031、2016/07-2019/07、整合microRNA與mRNA表達譜識別復雜疾病風險通路、6萬元、在研、主持。

v  國家自然科學基金青年項目,31401127、基于通路內部結構與通路間crosstalk識別復雜疾病風險通路的研究、2015/1-2017/12、20萬元、在研、參加。

v  于維漢院士杰出青年培養基金項目,無、無、2014/07-2017/06、30萬元、在研、主持。

v  國家自然科學基金青年項目,31200996、整合高通量基因、代謝子和通路結構信息的癌癥風險代謝通路區域系統識別、2013/1-2015/12、22萬元、在研、主持。

v  黑龍江省教育廳項目,12531295、復雜疾病風險代謝通路整合識別方法研究,2013/1-2015/12、2萬元、在研、主持。

v  國家教育部高等學校博士點學科專項科研基金項目,20102307120027,疾病代謝子通路融合挖掘及網絡分析方法研究、2011/01-2013/12、3.6萬元、已結題、主持。

v  黑龍江省研究生創新基金(重點)項目,YJSCX2011-316HLJ、融合基因組和代謝組進行復雜疾病風險代謝通路區域精細識別、2011/9-2012/7、5萬元、已結題、申請人。

v  國家自然科學基金重大研究計劃項目,91029717、融合組學挖掘非可控性炎癥向癌癥轉化的分子機制、2011/1-2013/12、60萬、已結題、參加。

v  國家自然科學基金面上項目,30871394、復雜疾病關聯的miRNA-mRNA功能模塊識別的信息融合方法研究、2009/1-2011/12、33萬元、已結題、參加。

發表SCI研究論文的目錄(標記#者為共同第一作者,標記*者為通訊或共同通訊作者)

2009年:

1.        Li C (李春權), Li X*, Miao Y, Wang Q, Jiang W, Xu C, Li J, Han J, Zhang F, Gong B, Xu L. SubpathwayMiner: a software package for flexible identification of pathways. Nucleic acids research. 2009;37(19):e131.SCI影響因子IF=9.2

2011年:

2.        Li J#, Gong B#, Chen X, Liu T, Wu C, Zhang F, Li C (李春權), Li X*, Rao S*. DOSim: an R package for similarity between diseases based on Disease Ontology. BMC bioinformatics. 2011;12:266.

3.        Xu J#, Li C#, Li Y, Lv J, Ma Y, Shao T, Xu L, Wang Y, Du L, Zhang Y, Jiang W, Li C (李春權), Xiao Y, Li X*. MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features. Nucleic acids research. 2011;39(3):825-836.SCI影響因子IF=9.2

4.        Li X#*, Li C (李春權)#, Shang D#, Li J, Han J, Miao Y, Wang Y, Wang Q, Li W, Wu C, Zhang Y, Li X, Yao Q. The implications of relationships between human diseases and metabolic subpathways. PLoS One. 2011;6(6):e21131.

5.        Qiao W, Cheng H, Li C (李春權), Jin H, Yang S, Li X, Zhang Y*. Identification of pathways involved in paclitaxel activity in cervical cancer. Asian Pacific journal of cancer prevention : APJCP. 2011;12(1):99-102.

2012年:

6.        Qiu F#, Xu Y#,*, Li K#, Li Z#, Liu Y#, DuanMu H, Zhang S, Chang Z, Zhou Y, Zhang R, Li C (李春權), Zhang Y, Liu M, Li X. CNVD: text mining-based copy number variation in disease database. Human mutation. 2012;33(11):E2375-81.SCI影響因子IF=6.0

7.        Li C (李春權)#, Han J#, Shang D#, Li J, Wang Y, Zhang Y, Yao Q, Zhang C, Li K*, Li X*. Identifying disease related sub-pathways for analysis of genome-wide association studies. Gene. 2012;503(1):101-109.

8.        Li C (李春權)#, Shang D#, Wang Y#, Li J, Han J, Wang S, Yao Q, Wang Y, Zhang Y, Zhang C, Xu Y, Jiang W, Li X*. Characterizing the network of drugs and their affected metabolic subpathways. PLoS One. 2012;7(10):e47326.

2013年:

9.        Li C (李春權)#, Han J#, Yao Q#, Zou C, Xu Y, Zhang C, Shang D, Zhou L, Sun Z, Li J, Zhang Y, Yang H, Gao X*, Li X*. Subpathway-GM: identification of metabolic subpathways via joint power of interesting genes and metabolites and their topologies within pathways. Nucleic acids research. 2013;41(9):e101.SCI影響因子IF=9.2

10.    Liu W#, Li C (李春權)#, Xu Y, Yang H, Yao Q, Han J, Shang D, Zhang C, Su F, Li X, Xiao Y, Zhang F, Dai M*, Li X*. Topologically inferring risk-active pathways toward precise cancer classification by directed random walk. Bioinformatics. 2013;29(17):2169-2177.SCI影響因子IF=5.7

11.    Wu B#, Luo L#, Li C (李春權), Xie J, Du Z, Wu J, Zhang P, Xu L*, Li E*. Comprehensive bioinformation analysis of the mRNA profile of fascin knockdown in esophageal squamous cell carcinoma. Asian Pacific journal of cancer prevention : APJCP. 2013;14(12):7221-7227.

12.    Shi H, Xu J, Zhang G, Xu L, Li C (李春權), Wang L, Zhao Z, Jiang W, Guo Z*, Li X*. Walking the interactome to identify human miRNA-disease associations through the functional link between miRNA targets and disease genes. BMC systems biology. 2013;7:101.

13.    Zhang F#, Gao B#, Xu L, Li C (李春權), Hao D, Zhang S, Zhou M, Su F, Chen X, Zhi H, Li X*. Allele-specific behavior of molecular networks: understanding small-molecule drug response in yeast. PLoS One. 2013;8(1):e53581.

14.    Wu B#, Li C (李春權)#, Zhang P, Yao Q, Wu J, Han J, Liao L, Xu Y, Lin R, Xiao D, Xu L, Li E*, Li X*. Dissection of miRNA-miRNA interaction in esophageal squamous cell carcinoma. PLoS One. 2013;8(9):e73191.

2014年:

15.    Wu B#, Li C(李春權)#, Du Z, Yao Q, Wu J, Feng L, Zhang P, Li S, Xu L*, Li E*. Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma. Sci Rep. 2014 Jun 23;4:5403.SCI影響因子IF=5.2

16.    Li F#, Xu Y#, Shang D, Yang H, Liu W, Han J, Sun Z, Yao Q, Zhang C, Ma J, Su F, Feng L, Shi X, Zhang Y, Li J, Gu Q, Li X*, Li C (李春權)*. MPINet: metabolite pathway identification via coupling of global metabolite network structure and metabolomic profile. Biomed Res Int. 2014;2014:325697.

17.    Wu B#, Li C (李春權)#, Du Z, Zhou F, Xie J, Luo L, Wu J, Zhang P, Xu L*, Li E*. Functional analysis of the mRNA profile of neutrophil gelatinaseassociated lipocalin overexpression in esophageal squamous cell carcinoma using multiple bioinformatic tools. Mol Med Rep. 2014 Oct;10(4):1800-1812.

18.    Zhang C#, Li C (李春權)#, Li J#, Han J, Shang D, Zhang Y, Zhang W, Yao Q, Han L, Xu Y, Yan W, Bao Z, You G, Jiang T*, Kang C*, Li X*. Identification of miRNA-mediated core gene module for glioma patient prediction by integrating high-throughput miRNA, mRNA expression and pathway structure. PLoS One. 2014 May 8;9(5):e96908.

19.    Shang D#, Li C (李春權)#, Yao Q#, Yang H, Xu Y, Han J, Li J, Su F, Zhang Y, Zhang C, Li D*, Li X*. Prioritizing Candidate Disease Metabolites Based on Global Functional Relationships between Metabolites in the Context of Metabolic Pathways. PLoS One. 2014 Aug 25;9(8):e104934.

20.    Li J, Li C (李春權), Han J, Zhang C, Shang D, Yao Q, Zhang Y, Xu Y, Liu W, Zhou M, Yang H, Su F, Li X*. The detection of risk pathways, regulated by miRNAs, via the integration of sample-matched miRNA-mRNA profiles and pathway structure. J Biomed Inform. 2014 June;49:187-197.

21.    Chen S#, Li C (李春權)#, Wu B, Zhang C, Liu C, Lin X, Wu X, Sun L, Chen B, Zhong Z*, Xu L*, Li E. Identification of differentially expressed genes and their subpathways in recurrent versus primary bone giant cell tumors. Int J Oncol. 2014 Sep;45(3):1133-1142.

22.    Li J#, Zhang Y#, Wang Y#, Zhang C, Wang Q, Shi X, Li C (李春權), Zhang R*, Li X*. Functional combination strategy for prioritization of human miRNA target. Gene. 2014;533(1):132-141.

2015年:

 

23.    Liu W#, Bai X#, Liu Y#, Wang W, Han J, Wang Q, Xu Y, Zhang C, Zhang S, Li X, Ren Z, Zhang J*, Li C (李春權)*. Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case. Sci Rep. 2015 Aug 19;5:13192. SCI影響因子IF=5.2

24.    Feng L#, Xu Y#, Zhang Y#, Sun Z, Han J, Zhang C, Yang H, Shang D, Su F, Shi X, Li S, Li C (李春權) *, Li X*. Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies. Oncotarget. 2015 Oct 12. doi: 10.18632/oncotarget.5341. SCI影響因子IF=5.0

25.    Han J#, Shi X#, Zhang Y#, Xu Y, Jiang Y, Zhang C, Feng L, Yang H, Shang D, Sun Z, Su F, Li C (李春權) *, Li X*. ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis. Sci Rep. 2015 Aug 12;5:13044. doi: 10.1038/srep13044. SCI影響因子IF=5.2

26.    Yao Q#, Xu Y#, Yang H, Shang D, Zhang C, Zhang Y, Sun Z, Shi X, Feng L, Han J, Su F, Li C (李春權) *, Li X*. Global Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network. Sci Rep. 2015 Nov 24;5:17201. SCI影響因子IF=5.2

27.    Han J#, Li C (李春權)#, Yang H#, Xu Y, Zhang C, Ma J, Shi X, Liu W, Shang D, Yao Q, Zhang Y, Su F, Feng L, Li X*. A novel dysregulated pathway-identification analysis based on global influence of within-pathway effects and crosstalk between pathways. Journal of the Royal Society Interface. 2015 Jan 6;12(102):20140937.

28.    Lv W#, Wang Q#, Chen H#, Jiang Y#, Zheng J, Shi M, Xu Y, Han J, Li C (李春權) *, Zhang R*. Prioritization of rheumatoid arthritis risk subpathways based on global immune subpathway interaction network and random walk strategy. Mol Biosyst. 2015 Oct 13;11(11):2986-97.

29.    Liu W#, Wang Q#, Zhao J, Zhang C, Liu Y, Zhang J, Bai X, Li X, Feng H, Liao M, Wang W*, Li C (李春權)*. Integration of pathway structure information into a reweighted partial Cox regression approach for survival analysis on high-dimensional gene expression data. Mol Biosyst. 2015 Jul;11(7):1876-86.

30.    Zhang J#, Wang Y#, Shang D#, Yu F, Liu W, Zhang Y, Feng C, Wang Q, Xu Y, Liu Y, Bai X, Li X, Li C (李春權)*. Characterizing and optimizing human anticancer drug targets based on topological properties in the context of biological pathways. J Biomed Inform. 2015 Apr;54:132-140.

31.    Shang D#, Yang H#, Xu Y, Yao Q, Zhou W, Shi X, Han J, Su F, Su B, Zhang C, Li C (李春權)*, Li X*. A global view of network of lncRNAs and their binding proteins. Mol Biosyst. 2015 Feb;11(2):656-663.

32.    Deng L, Xu Y, Zhang C, Yao Q, Feng L, Li C (李春權)*. A network-based strategy from the global perspective for identification of risk pathways in complex diseases. Prog Biochem Biophys. 2015 Jan 15;42(3):11.

33.    Zhang C#, Li C (李春權)#, Xu Y#, Feng L, Shang D, Yang X, Han J, Sun Z, Li Y*, Li X*. Integrative analysis of lung development-cancer expression associations reveals the roles of signatures with inverse expression patterns. Mol Biosyst. 2015 May; PubMed PMID: 25720795.

34.    Chen X, Wang Y, Wang P, Lian B, Li C (李春權), Wang J, Li X, Jiang W. Systematic Analysis of the Associations between Adverse Drug Reactions and Pathways. Biomed Res Int. 2015;2015:670949.

35.    Zhang Y, Liu W, Xu Y, Li C (李春權), Wang Y, Yang H, Zhang C, Su F, Li Y*, Li X*. Identification of subtype specific miRNA-mRNA functional regulatory modules in matched miRNA-mRNA expression data: multiple myeloma as a case. Biomed Res Int. 2015 Mar 19;2015:501262.

2016年:

 

36.    Song C#, Zhang J#, Liu Y, Pan H, Qi HP, Cao YG, Zhao JM, Li S, Guo J, Sun HL*, Li CQ (李春權)*. Construction and analysis of cardiac hypertrophy-associated lncRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in cardiac hypertrophy. Oncotarget. 2016 Mar 8;7(10):10827-40. SCI影響因子IF=5.0

37.    Feng C#, Zhang J#, Li X#, Ai B, Han J, Wang Q, Wei T, Xu Y, Li M, Li S, Song C, Li C (李春權)*. Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways. Sci Rep. 2016 Sep 14;6:33262. SCI影響因子IF=5.2

38.    Li S, Xu Y, Sun Z, Feng L, Shang D, Zhang C, Shi X, Han J, Su F, Yang H, Zhao J, Song C, Zhang Y, Li C (李春權)*, Li X*. Identification of a lncRNA involved functional module for esophageal cancer subtypes. Mol Biosyst. 2016 Aug 19. PubMed PMID: 27539139.

39.    Zhao J#, Li X#,Yao Q#, Li M, Zhang J, Ai B, Liu W, Wang Q, Feng C, Liu Y, Bai X, Song C, Li S, Li E, Xu L*, Li C (李春權)*. RWCFusion: identifying phenotype-specific cancer driver gene fusions based on fusion pair random walk scoring method. Oncotarget. 2016 Aug 5. PubMed PMID: 27506935. SCI影響因子IF=5.0

40.    Shi X#, Xu Y#, Zhang C, Feng L, Sun Z, Han J, Su F, Zhang Y*, Li C (李春權)*, Li X*. Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies. Oncotarget. 2016 Sep 13. PubMed PMID:27634882. SCI影響因子IF=5.0

41.    Han J#, Liu S#, Zhang Y#, Xu Y, Jiang Y, Zhang C, Li C (李春權)*, Li X*. MiRSEA: Discovering the pathways regulated by dysfunctional MicroRNAs. Oncotarget. 2016 Jul 26. PubMed PMID: 27474169. SCI影響因子IF=5.0

42.    Guo JC, Li CQ(李春權), Wang QY, Zhao JM, Ding JY, Li EM*, Xu LY*. Protein-coding genes combined with long non-coding RNAs predict prognosis in esophageal squamous cell carcinoma patients as a novel clinical multi-dimensional signature. Mol Biosyst. 2016 Sep 23. PubMed PMID: 27714034.

43.    Zou HY, Lv GQ, Dai LH, Zhan XH, Jiao JW, Liao LD, Zhou TM, Li CQ (李春權), Wu BL, Xu LY*, Li EM*. A truncated splice variant of human lysyl oxidase-like 2 promotes migration and invasion in esophageal squamous cell carcinoma. Int J Biochem Cell Biol. 2016 Jun;75:85-98.

2017年:

 

44.    Han J, Liu S, Sun Z, Zhang Y, Zhang F, Zhang C, Shang D, Yang H, Su F, Xu Y,Li C, Ren H, Li X. LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method. Sci Rep. 2017 Apr 20;7:46566.

45.    C-Q Li, G-W Huang, Z-Y Wu, Y-J Xu, X-C Li, Y-J Xue, Y Zhu, J-M Zhao, M Li, J Zhang, J-Y Wu, F Lei, Q-Y Wang, S Li, C-P Zheng, B Ai, Z-D Tang, C-C Feng, L-D Liao, S-H Wang, J-H Shen, Y-J Liu, X-F Bai, J-Z He, H-H Cao, B-L Wu, M-R Wang, D-C Lin, HP Koeffler, L-D Wang, X Li, E-M Li and L-Y Xu1Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. Oncogenesis 2017 6, e297; doi:10.1038/oncsis.

 

 

 

 


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版權所有:哈爾濱醫科大學大慶校區
地址:黑龍江省大慶市高新區新陽路39
黑ICP備2021002235號
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